Relevant Publications

  1. Natesh R., Schwager S.L., Sturrock E.D., Acharya K.R. (2003) Crystal structure of the human angiotensin-converting enzyme-lisinopril complex. Nature 421, 551-4.

  2. Acharya, K.R., Riordan, J.F., Sturrock, E.D., Ehlers, M.R.W. (2003) Angiotensin-converting enzyme: A new target for structure-based drug design. Nature Reviews Drug Discovery 2(11), 891-902.

  3. Natesh, R., Schwager, S.L., Evans, H.R., Sturrock, E.D., Acharya, K.R. (2004) Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme Biochemistry 43, 8718-8724.

  4. Corradi, H.R., Schwager, S.L.U., Nchinda, A. T., and Sturrock, E.D., and Acharya, K.R. (2006) Crystal structure of the N domain of human somatic angiotensin-I converting enzyme provides a structural basis for domain-specific inhibitor design.  J.Mol. Biol. 357(3), 964-74.

  5. Nchinda, A. T., Chibale, K., Redelinghuys, P., and Sturrock, E.D (2006) Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme. Bioorg. Med. Chem. Lett 16(17), 4616-4619.

  6. Corradi, H.R., Chitapi, I., Sewell, B. T., Georgiadis, D., Dive, V., Sturrock, E. D., and Acharya, K. R. (2007) The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380. Biochemistry 46(18), 5473-5478.

  7. Watermeyer J.M., Kröger W.L., O'Neill H.G., Sewell B.T., Sturrock E.D. (2010) Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril. Biochem. J. 428(1), 67-74.

  8. Anthony, C.S., Corradi, H.R., Schwager, S.L.U., Redelinghuys, P., Acharya, K.R., Sturrock, E.D. (2010) The N domain of human angiotensin-I converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain specific phosphinic inhibitor RXP407. J. Biol. Chem. 285(46), 35685-93.

  9. Denti P, Sharp SK, Kröger WL, Schwager SL, Mahajan A, Njoroge M, Gibhard L, Smit I, Chibale K, Wiesner L, Sturrock ED, Davies NH (2014) Pharmacokinetic evaluation of lisinopril-tryptophan, a novel C-domain ACE inhibitor.  Eur J Pharm Sci 56, 113-9.